Bug #8 Added by Eugenio Piasini about 13 years ago. Updated about 13 years ago.

GranCell_mod should match GRANULE_Cell's behaviour

Status:
Closed
Priority:
Normal
Assignee:
-
Start date:
06 Mar 2012
Due date:
% Done:

0%


Description

We have to make sure that the neuroconstruct model which uses the mod files from the original NEURON implementation behaves exactly as the reference model. As of Revision r7, this doesn't appear to be true: I attach a comparison between the two cells obtained by simulating a simple current injection as per the test.py script at 30 deg C.
!attached_image!

GranCellSolinasEtAl10_test_rev7.png View (66 KB) Eugenio Piasini, 06 Mar 2012 17:14

GranCellSolinasEtAl10_test_rev8_NMDALeak_noTABLEKCa.png View (77.2 KB) Eugenio Piasini, 07 Mar 2012 00:29

GranuleCellSolinasEtAl10_test_r8.png View (67.5 KB) Sergio Solinas, 08 Mar 2012 17:10

History

#1 Updated by Eugenio Piasini about 13 years ago

  • File GranCellSolinasEtAl10_test_rev7_NMDALeak_noTABLEKCa.png added

Revision r8
* Added the NMDA_Leak mechanism
* commented out the TABLE and DEPEND lines in GRANULE_KCA.mod (in the nC project) to mimic the effect of the


h.usetable_GRANULE_KCA = 0

setting in GRANULE_Cell.py.

However, it still doesn't match: see attached graph.
!GranCellSolinasEtAl10_test_rev8_NMDALeak_noTABLEKCa.png!

#2 Updated by Eugenio Piasini about 13 years ago

  • File deleted (GranCellSolinasEtAl10_test_rev7_NMDALeak_noTABLEKCa.png)

#4 Updated by Sergio Solinas about 13 years ago

  • !GranuleCellSolinasEtAl10_test_r8.png!
  • I disagree with Eugenio simulation results, in my simulations the overlap between test.py and the nC version is remarkable.

#5 Updated by Eugenio Piasini about 13 years ago

  • Status changed from New to Resolved

My bad. In my previous simulations, I had left the temperature in test.py at 37 instead of 30. I confirm that rev r8(:63ed761a1024) fixes the issue. I'm going to merge back this fix in the repo's default branch.

#6 Updated by Eugenio Piasini about 13 years ago

  • Status changed from Resolved to Closed