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Boris Marin, 18 Jun 2014 16:52
1 | 7 | Boris Marin | # L5 Pyramidal Neuron Almog and Korngreen (2014) |
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2 | 1 | Boris Marin | |
3 | 7 | Boris Marin | ## Model description |
4 | 7 | Boris Marin | This model originally appeared in **Almog M., Korngreen A.** *A Quantitative Description of Dendritic Conductances and Its Application to Dendritic Excitation in Layer 5 Pyramidal Neurons* [J Neurosci 34(1):1](http://www.jneurosci.org/content/34/1/182). The relevant *neuron* files can be downloaded from [modelDB](http://senselab.med.yale.edu/modeldb/ShowModel.asp?model=151825). |
5 | 1 | Boris Marin | |
6 | 7 | Boris Marin | ## Conversion to NeuroML |
7 | 7 | Boris Marin | |
8 | 1 | Boris Marin | We have converted the [original model](http://senselab.med.yale.edu/modeldb/ShowModel.asp?model=151825) to NeuroML. Most *.mod* mechanisms can be mapped to [ChannelML](http://neuroml.org/NeuroMLValidator/Transform.jsp?localFile=NeuroMLFiles/Schemata/v1.8.1/Level2/ChannelML_v1.8.1.xsd&xslFile=NeuroMLFiles/Schemata/XSD_Readable.xsl) with exception of the Calcium mechanisms described in terms of the [GHK](http://en.wikipedia.org/wiki/GHK_flux_equation) formalism. These latter needed to be translated to [NeuroML2](http://www.neuroml.org/neuroml2.php), which supports arbitrary current laws. |
9 | 5 | Boris Marin | |
10 | 7 | Boris Marin | The NeuroML version reproduces the results from the *bac6.ses* script bundled with the [modelDB](http://senselab.med.yale.edu/modeldb/ShowModel.asp?model=151825) version, taking into account that some [issues](https://github.com/OpenSourceBrain/korngreen-pyramidal/issues). |
11 | 5 | Boris Marin | |
12 | 7 | Boris Marin | ### *NeuroConstruct* project |
13 | 7 | Boris Marin | #### Ionic Mechanisms |
14 | 7 | Boris Marin | Both original and NeuroML versions of the ionic mechanisms were imported into a *neuroConstruct* project, with simulation configurations allowing the comparison of both implementations. Mechanisms were named according the following convention: the original *.mod* mechanisms were suffixed with *_nrn*, while the NeuroML mechanisms had no suffix. |
15 | 1 | Boris Marin | |
16 | 7 | Boris Marin | #### Morphology |
17 | 7 | Boris Marin | Cell [morphology](http://senselab.med.yale.edu/modeldb/ShowModel.asp?model=151825&file=\Demo\cells\A140612.hoc) from the *modelDB* project was exported to NeuroML using *neuron*. |
18 | 7 | Boris Marin | |
19 | 7 | Boris Marin | ### Idiosyncrasies in the conversion |
20 | 7 | Boris Marin | #### General issues |
21 | 7 | Boris Marin | General comments/difficulties that occurred during the conversion are logged on the github repo as [issues](https://github.com/OpenSourceBrain/korngreen-pyramidal/issues). |
22 | 7 | Boris Marin | |
23 | 7 | Boris Marin | #### Inhomogeneous parameters over the dendritic tree |
24 | 7 | Boris Marin | ![](gih_comparison.png) |
25 | 7 | Boris Marin | The original *neuron* version results in piecewise linear interpolation of the distribution over each section. Compare the *neuroConstuct* generated code |
26 | 7 | Boris Marin | |
27 | 7 | Boris Marin | //neuroconstruct generated |
28 | 7 | Boris Marin | objref PathLengthApicalDends |
29 | 7 | Boris Marin | PathLengthApicalDends = new SubsetDomainIterator |
30 | 7 | Boris Marin | PathLengthApicalDends.update { |
31 | 7 | Boris Marin | x = PathLengthApicalDends.x |
32 | 7 | Boris Marin | p = PathLengthApicalDends.p |
33 | 7 | Boris Marin | gmax\_iA = 100000.0** (2.82824E-4 + (0.0033165 \* exp(((–1) \* 0.0117721) \* p))) // 100000.0 to convert from nc to NEURON units |
34 | 7 | Boris Marin | } |
35 | 7 | Boris Marin | |
36 | 4 | Boris Marin | With the original *.hoc* specification |
37 | 4 | Boris Marin | |
38 | 4 | Boris Marin | gbar_iA(0:1) = (gka_start+gka_beta*exp(gka_alpha*dist1)):(gka_start+gka_beta*exp(gka_alpha*dist2)) |