Introduction

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This project contains a neuroConstruct project which generates a version of the pyloric pacemaker model. The channel models have been converted to ChannelML and the network can be exported to:

- [NeuroML v1.8.1](https://github.com/OpenSourceBrain/PyloricNetwork/tree/master/neuroConstruct/generatedNeuroML)

- NEURON

- GENESIS

- MOOSE

- [NeuroML v2beta2](https://github.com/OpenSourceBrain/PyloricNetwork/tree/master/neuroConstruct/generatedNeuroML2)

This is based on work by Aditya Gilra, Boris Marin and Padriag Gleeson. A unified version of the neuroConstruct model is in the top level [neuroConstruct](https://github.com/OpenSourceBrain/PyloricNetwork/tree/master/neuroConstruct) folder.

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Aditya Gilra's original implementation of the pyloric pacemaker model of the lobster somatogastric ganglion 

system in the [AdityaGilraMOOSEnC](https://github.com/OpenSourceBrain/PyloricNetwork/tree/master/AdityaGilraMOOSEnC) folder.

The 3 cell network is for fig 3d from :

Similar network activity from disparate circuit parameters

Astrid A Prinz, Dirk Bucher & Eve Marder

[Nature Neuroscience 7, 1345 - 1352, 2004](http://www.nature.com/neuro/journal/v7/n12/abs/nn1352.html)

The cell models and channel mechanisms are from:

Alternative to Hand-Tuning Conductance-Based Models: Construction and Analysis of Databases of Model Neurons

Astrid A. Prinz, Cyrus P. Billimoria, and Eve Marder,

[J Neurophysiol 90: 3998–4015, 2003](http://jn.physiology.org/content/90/6/3998.abstract?cited-by=yes&legid=jn;90/6/3998)

The same cell is used as the basis for 3 cells AB\_PD, LP and PY with different channel densities,

 connected in the pyloric rhythm generator network specified in Fig 3d of Prinz, Bucher and Marder, 2004 above.

Differences from the original model: synapses are thresholded rather than graded.

This is in the neuroConstruct\_alt directory and currently runs on MOOSE buildQ branch.

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Boris Marin’s version: 

Electrophysiological data comes from this article: Gina Turrigiano, Gwendal LeMasson, and Eve Marder

Selective regulation of current densities underlies spontaneous changes in the activity of cultured neurons

[Journal of Neuroscience, 15(5 Pt 1), 3640–52, 1995](http://www.ncbi.nlm.nih.gov/pubmed/7538565)

Model transcribed from this article: Astrid A. Prinz, Vatsala Thirumalai, and Eve Marder

The functional consequences of changes in the strength and duration of synaptic inputs to oscillatory neurons

[Journal of Neuroscience, 23(3), 943–54, 2003](http://www.ncbi.nlm.nih.gov/pubmed/12574423)