Edit History

Wiki » History » Version 12

Vitor Chaud, 30 Apr 2014 14:57

1 1 Vitor Chaud
Model overview
2 2 Vitor Chaud
==============
3 1 Vitor Chaud
4 4 Vitor Chaud
[Vogels et al 2011](http://www.sciencemag.org/content/334/6062/1569.short) provides an extension of the model described in [Vogels and Abbott 2005](http://www.jneurosci.org/content/25/46/10786.short) mainly in order to evaluate the role of inhibitory synapse plasticity in recovering an asynchronous network state after a manifestation of some memory pattern (i.e., highly correlated activity of some neuron group).
5 4 Vitor Chaud
6 5 Vitor Chaud
A brief video illustrating model features can be found [here](http://lcn.epfl.ch/~vogels/index_movie.html).
7 5 Vitor Chaud
8 1 Vitor Chaud
Downloading and running a simulation
9 1 Vitor Chaud
====================================
10 1 Vitor Chaud
11 5 Vitor Chaud
To get local clone of this project [Install Git](http://www.opensourcebrain.org/projects/gitintro/wiki/Wiki), go to the directory in which the project will be cloned and type:
12 1 Vitor Chaud
13 1 Vitor Chaud
    > git clone https://github.com/OpenSourceBrain/VogelsEtAl2011.git
14 1 Vitor Chaud
15 5 Vitor Chaud
In order to install PyNN see http://neuralensemble.org/trac/PyNN/wiki/Installation. Make sure to use the latest v0.8 version from [GitHub](https://github.com/NeuralEnsemble/PyNN), which includes the required Vogels2011Rule synapse. Note: NEURON is the only supported simulator for this model at the moment.
16 5 Vitor Chaud
17 5 Vitor Chaud
Go to the PyNN subdirectory:
18 5 Vitor Chaud
19 1 Vitor Chaud
    > cd VogelsEtAl2011/PyNN
20 1 Vitor Chaud
21 1 Vitor Chaud
To run a simulation type:
22 1 Vitor Chaud
23 1 Vitor Chaud
    > python vogelsEtAl2011.py neuron
24 5 Vitor Chaud
25 5 Vitor Chaud
Version of the project
26 5 Vitor Chaud
======================
27 5 Vitor Chaud
28 5 Vitor Chaud
A Matlab code using the original model implementation can be found [here](http://senselab.med.yale.edu/ModelDB/ShowModel.asp?model=143751).
29 5 Vitor Chaud
30 5 Vitor Chaud
The project described here is still under development and NEURON is the only supported simulator for this model at the moment.
31 6 Vitor Chaud
32 6 Vitor Chaud
![](test_fullNetwork_dw100.png)
33 7 Vitor Chaud
34 7 Vitor Chaud
table{border:1px solid black}.
35 10 Vitor Chaud
{background:\#ddd}. |*=.State|*=.Description|\_=.Original simulation time|
36 11 Vitor Chaud
|=. **pre**|The asynchronous irregular network dynamics of the model published in Vogels and Abbott (2005) without inhibitory plasticity|1 min (60000 ms)|
37 12 Vitor Chaud
|={background:\#eee}. **A** |{background:\#eee}. Inhibitory to excitatory synapses are turned to 0 efficacy. The network is forced out of the AI regime and begins to fire
38 12 Vitor Chaud
 at high rates. Inhibitory plasticity is turned on.|{background:\#eee}. Not specified|
39 9 Vitor Chaud
|=. **B** |Inhibitory plasticity has restored asynchronous irregular dynamics|60 min (60\*60\*1000 ms)|
40 9 Vitor Chaud
|={background:\#eee}. **C** |{background:\#eee}.The excitatory non-zero weights of the two designated memory
41 9 Vitor Chaud
 patterns are increased ad-hoc by a factor of 5. The neurons of hte subset
42 9 Vitor Chaud
 begin to exhibit elevated and more sychronized activity|{background:\#eee}.5 sec (5000 ms)|
43 9 Vitor Chaud
|=. **D** |Inhibitory plasticity has succesfully suppressed any elevated activity
44 9 Vitor Chaud
 from the pattern and restored the global background state|60 min (60\*60\*1000 ms)|
45 9 Vitor Chaud
|={background:\#eee}. **E** |{background:\#eee}.By delivering an additional, 1 s long stimulus as described above to
46 9 Vitor Chaud
 25% of the cells within one memory pattern, the whole pattern is activated.
47 9 Vitor Chaud
 Activity inside the pattern stays asynchronous and irregular, and the rest of
48 9 Vitor Chaud
 the network, including the other pattern, ramains nearly unaffected|{background:\#eee}.5 sec (5000 ms)|