Revision:

Revisions

# Date Author Comment
3dbcc0c2 21 Sep 2012 17:17 Eugenio Piasini

Made the second apical dendrite identical to the first one.

631f457e 21 Sep 2012 15:06 Eugenio Piasini

Added two new scripts to better reproduce figure 3C in Vervaeke2012.

Koen clarified via email that the cell being tested was 210710_C1,
that the attenuation was measured over an apical dendrite (one that he
could have pathced during the experiments), and that it wasn't...

3080441e 21 Sep 2012 14:53 Eugenio Piasini

Minor: removed superfluous line.

4d768b43 20 Sep 2012 16:31 Eugenio Piasini

Minor fitting and plotting adjustments.

58ac1787 20 Sep 2012 16:30 Eugenio Piasini

Created a segment group for each of the apical dendrites in C1.

36e32302 20 Sep 2012 12:58 Eugenio Piasini

Added a (0,1) point in attenuation fit because of normalisation.

07e2707a 20 Sep 2012 12:58 Eugenio Piasini

Added a new segment group representing a single apical dendrite.

93ddc84c 20 Sep 2012 11:29 Eugenio Piasini

Included the 240710_C0 model, as an alternative to 210710_C1.

Imported the model and modified the relevant simulation/analysis
scripts. Note that setting sodium and potassium reversal potential over
the whole cell crashes neuroConstruct for some reason.

32ded58d 18 Sep 2012 17:41 Eugenio Piasini

Revert "Begun importing other version of detailed morphology GoC."

This reverts commit be055a8cbbf8955c1fc67608f7be31bddc890804.

be055a8c 18 Sep 2012 17:10 Eugenio Piasini

Begun importing other version of detailed morphology GoC.

3d50f15c 18 Sep 2012 15:41 Eugenio Piasini

Varying the number of stimulation points on the detailed dendrites.

Still fairly hard-coded, but at least I now have more than 3 points for
the exponential fit on the detailed morphology.

a1363158 14 Sep 2012 17:21 Eugenio Piasini

Removed recording of superfluous data during simulations.

c2c23cff 14 Sep 2012 16:50 Eugenio Piasini

Scripts seem to be working fine.

Attenuation seems to match between the two models
(at least with the 4-5-6 dendrite on the reduced
morphology and a specific choice of compartments
on the detailed one), but they both seem to give
different results than those in the paper.

23e72a77 14 Sep 2012 14:50 Eugenio Piasini

Tidied up the code.

ed62ce34 13 Sep 2012 16:14 Eugenio Piasini

Working on the simulation/analysis scripts.

Added plotting of dependance of maximum somatic response amplitude
on distance of stimulation along the dendritic tree.

ab253e75 13 Sep 2012 15:57 Eugenio Piasini

Leak conductance on both models has been set to 6.67e-10mSum-2,
as per supplementary information (page 3) in Vervaeke2012, where
15kOhmcm2 was reported from unpublished observations.

Also, fixed the (wrong) number of internal divisions of a segment.

e1320be9 13 Sep 2012 13:39 Eugenio Piasini

Still playing around with reduced morphology. Added an axon.

18f23cd8 12 Sep 2012 17:46 Eugenio Piasini

Playing around with morphology to see effects on FI and attenuation.

575383cc 12 Sep 2012 16:13 Eugenio Piasini

Adjusted spike detection threshold to avoid picking up doublets
in the Vervaeke cell when calculating the F-I curve.

f920ef97 12 Sep 2012 15:42 Eugenio Piasini

Added scripts for simulating and plotting an F-I curve comparison.

9b116d9d 12 Sep 2012 13:38 Eugenio Piasini

Integrating fast segment-to-soma distance calculation in nC
allows to meaningfully compare dendritic attenuation effects
on different (and complex) morphologies.

dce3c5dd 12 Sep 2012 13:34 Eugenio Piasini

Fixed a remaining issue with the detailed morphology cell.

Note that I turned off again all Na channels.

Now pure NeuroML morphology read/write seems to be working fine,
except that it removes property elements tagged 'comment'.
This will need to be fixed in neuroConstruct, but doesn't have...

7a50584e 12 Sep 2012 11:28 Eugenio Piasini

Reverted morphologically-detailed cell model back to its original form
to fix some issues (namely, loss of 'number of internal divisions'
properties) generated when doing NeuroML write/read with older versions
of neuroConstruct.

cc5e5cec 12 Sep 2012 11:12 Eugenio Piasini

Modified leak conductance to match what Koen did.

f878dab0 11 Sep 2012 13:38 Eugenio Piasini

Comparing attenuation in the original (Koen's) model and in my reduced one.

Important: to get to a meaningful comparison,
I'm tweaking the spatial discretisation of the original model.

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