We used L5 Pyr neuron models fit to electrophysiology data from younger and older individuals to simulate detailed human layer 5 microcircuits. These circuits also included detailed parvalbumin+ (PV), somatostatin+ (SST), and vasoactivate intestinal polypeptide+ (VIP) inhibitory interneuron models.

Guet-McCreight A, Chameh HM, Mahallati S, Wishart M, Tripathy SJ, Valiante TA, Hay E. (2022). Age-dependent increased sag amplitude in human pyramidal neurons dampens baseline cortical activity. Cereb. Cortex. DOI: https://doi.org/10.1093/cercor/bhac348.